midD-encoded ‘rhizomimosinase’ from Rhizobium sp. strain TAL1145 is a C–N lyase that catabolizes L-mimosine into 3-hydroxy-4-pyridone, pyruvate and ammonia

ORIGINAL ARTICLE Vishal Singh Negi • Jon-Paul Bingham • Qing X. Li • Dulal Borthakur Received: 17 November 2012 / Accepted: 19 February 2013 / Published online: 6 March 2013 Springer-Verlag Wien 2013 Abstract Rhizobium sp. strain TAL1145 catabolizes mimosine, which is a toxic non-protein amino acid present in Leucaena leucocephala (leucaena). The objective of this investigation was to study the biochemical and catalytic properties of the enzyme encoded by midD, one of the TAL1145 genes involved in mimosine degradation. The

Chemical synthesis and orexigenic activity of rat/mouse relaxin-3

ORIGINAL ARTICLE Mohammed Akhter Hossain • Craig M. Smith • Philip J. Ryan • Elena Bu ¨chler • Ross A. D. Bathgate • Andrew L. Gundlach • John D. Wade Received: 24 January 2013 / Accepted: 18 February 2013 / Published online: 1 March 2013 Springer-Verlag Wien 2013 Abstract The insulin-like peptide, relaxin-3 was first identified just a decade ago via a genomic database search and is now recognized to be a key neuropeptide with several roles including the regulation of arousal, stress responses and neuroendocrine homeostasis. It also has

Dimerization of aurein 1.2: effects in structure, antimicrobial activity and aggregation of Ca ˆndida albicans cells

ORIGINAL ARTICLE E. N. Lorenzo ´n • P. R. S. Sanches • L. G. Nogueira • T. M. Bauab • E. M. Cilli Received: 1 December 2012 / Accepted: 14 February 2013 / Published online: 22 March 2013 Springer-Verlag Wien 2013 Abstract Antimicrobial peptides (AMPs) are a promising solution to face the antibiotic-resistant problem because they display little or no resistance effects. Dimeric analogues of select AMPs have shown pharmacotechnical advantages, making these molecules promising candidates for the development of novel antibiotic agents. Here, we

Caffeine-containing energy drink improves sprint performance during an international rugby sevens competition

ORIGINAL ARTICLE Juan Del Coso • Javier Portillo • Gloria Mun ˜oz • Javier Abia ´n-Vice ´n • Cristina Gonzalez-Milla ´n • Jesu ´s Mun ˜oz-Guerra Received: 31 October 2012 / Accepted: 13 February 2013 / Published online: 5 March 2013 Springer-Verlag Wien 2013 Abstract The aim of this study was to determine the effects of a caffeine-containing energy drink on physical performance during a rugby sevens competition. A second purpose was to investigate the post-competition urinary caffeine concentration derived from the energy drink intake.

Protein and amino acid supplementation in older humans

INVITED REVIEW Naomi K. Fukagawa Received: 16 February 2013 / Accepted: 21 February 2013 / Published online: 6 April 2013 Springer-Verlag Wien 2013 Abstract The aging process is a continuum throughout life and often associated with deterioration of body function as well as accumulation of chronic disabilities and of disease. The impact of nutritional status on morbidity and mortality is unquestioned. Malnutrition increases the risk for frailty and nutritional deficits can influence immune status, response to medical treatments and recovery from

Carnosine: from exercise performance to health

INVITED REVIEW Craig Sale • Guilherme G. Artioli • Bruno Gualano • Bryan Saunders • Ruth M. Hobson • Roger C. Harris Received: 14 February 2013 / Accepted: 16 February 2013 / Published online: 12 March 2013 Springer-Verlag Wien 2013 Abstract Carnosine was first discovered in skeletal muscle, where its concentration is higher than in any other tissue. This, along with an understanding of its role as an intracellular pH buffer has made it a dipeptide of interest for the athletic population with its potential to increase high-intensity exercise performance and capacity. The

Analysis of DNA interactions using single-molecule force spectroscopy

INVITED REVIEW Markus Ritzefeld • Volker Walhorn • Dario Anselmetti • Norbert Sewald Received: 30 January 2013 / Accepted: 13 February 2013 / Published online: 7 March 2013 Springer-Verlag Wien 2013 Abstract Protein–DNA interactions are involved in many biochemical pathways and determine the fate of the corresponding cell. Qualitative and quantitative investigations on these recognition and binding processes are of key importance for an improved understanding of biochemical processes and also for systems biology. This review article

The pentosidine concentration in human blood specimens is affected by heating

SHORT COMMUNICATION Masako Nakano • Midori Kubota • Shigeru Owada • Ryoji Nagai Received: 10 August 2011 / Accepted: 22 November 2011 / Published online: 4 December 2011 Springer-Verlag 2011 Abstract Pentosidine is an advanced glycation end product, formed by oxidation and glycation that accumulates markedly during end-stage renal failure. Measurement of the pentosidine level in physiological samples is applied as a sensitive marker for the early diagnosis of renal failure. In the quantitative measurements of pentosidine reported to date, a rapid enzyme-linked immunosorbent

Digestibility of extruded proteins and metabolic transit of Ne-carboxymethyllysine in rats

ORIGINAL ARTICLE Issam Alamir • Ce ´line Niquet-Leridon • Philippe Jacolot • Camille Rodriguez • Martine Orosco • Pauline M. Anton • Fre ´de ´ric J. Tessier Received: 28 July 2012 / Accepted: 2 November 2012 / Published online: 16 November 2012 Springer-Verlag Wien 2012 Abstract Milk proteins are frequently used as supplements in fortified foods. However, processing produces chemical changes which likely affect the nutritional advantage. This study was intended to explore the possible

Activation of the transcription factor Nrf2 in macrophages, Caco-2 cells and intact human gut tissue by Maillard reaction products and coffee

ORIGINAL ARTICLE Tanja Sauer • Martin Raithel • Ju ¨rgen Kressel • Gerald Mu ¨nch • Monika Pischetsrieder Received: 12 April 2011 / Accepted: 12 January 2012 / Published online: 25 January 2012 Springer-Verlag 2012 Abstract In addition to direct antioxidative effects, Maillard reaction products (MRPs) could increase the antioxidative capacity of cells through the induction of cytoprotective enzymes. Since many of those enzymes are regulated by the transcription factor Nrf2, the effect of MRPs on nuclear translocation of Nrf2 in macrophages and


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