Раздел науки

Synthesis of the amino acid conjugates of epi-jasmonic acid

ORIGINAL ARTICLE N. Ogawa • Y. Kobayashi Received: 28 February 2011 / Accepted: 25 April 2011 / Published online: 12 May 2011 Springer-Verlag 2011 Abstract The TES ether of the C6-hydroxy derivative of naturally occurring epi-jasmonic acid (epi-JA) was designed as epimerization-free equivalent of epi-JA. The TES ether was synthesized from (1R,4S)-4-hydroxycyclopent-2-enyl acetate in 13 steps. The acid part of the ether was activated with ClCO2Bui and subjected to condensation with L-amino acid at room temperature for 48 h. The TES group in the

Using Markov model to improve word normalization algorithm for biological sequence comparison

ORIGINAL ARTICLE Qi Dai • Xiaoqing Liu • Yuhua Yao • Fukun Zhao Received: 13 November 2010 / Accepted: 29 March 2011 / Published online: 20 April 2011 Springer-Verlag 2011 Abstract There are two crucial problems with statistical measures for sequence comparison: overlapping structures and background information of words in biological sequences. Word normalization in improved composition vector method took into account these problems and achieved better performance in evolutionary analysis. The word normalization is desirable, but not sufficient, because

Biophysical characterization of recombinant HIV-1 subtype C virus infectivity factor

ORIGINAL ARTICLE Daniela Gallerano • Siva Charan Devanaboyina • Ines Swoboda • Birgit Linhart • Irene Mittermann • Walter Keller • Rudolf Valenta Received: 28 May 2010 / Accepted: 11 August 2010 / Published online: 31 August 2010 Springer-Verlag 2010 Abstract HIV-1 virus infectivity factor (Vif) is one of the four accessory proteins that are characteristic of primate lentiviruses and critically required for the infection of host cells. Vif plays a key role in replication and transmission of the virus in non-permissive cells, such as primary T cells

Preliminary kinetic characterization of a copper amine oxidase from rat liver mitochondria matrix

ORIGINAL ARTICLE Roberto Stevanato • Sara Cardillo • Michele Braga • Angela De Iuliis • Valentina Battaglia • Antonio Toninello • Enzo Agostinelli • Fabio Vianello Received: 27 May 2010 / Accepted: 17 July 2010 / Published online: 5 August 2010 Springer-Verlag 2010 Abstract Kinetic measurements of a novel copperdependent amine oxidase, purified from rat liver mitochondria matrix, were carried out using various substrates in a large pH (5.6–10.2) and ionic strength range (5–200 mM), in order to study the docking of substrates to the enzyme and, as

Prediction of protein structural class using a complexity-based distance measure

ORIGINAL ARTICLE Taigang Liu Æ Xiaoqi Zheng Æ Jun Wang Received: 25 November 2008 / Accepted: 11 March 2009 / Published online: 28 March 2009 Springer-Verlag 2009 Abstract Knowledge of structural class plays an important role in understanding protein folding patterns. So it is necessary to develop effective and reliable computational methods for prediction of protein structural class. To this end, we present a new method called NN-CDM, a nearest neighbor classifier with a complexity-based distance measure. Instead of extracting features from protein sequences

Novel sulfur and selenium containing bis-a-amino acids from 4-hydroxyproline

ORIGINAL ARTICLE Romualdo Caputo Æ Marina DellaGreca Æ Ivan de Paola Æ Domenico Mastroianni Æ Luigi Longobardo Received: 19 May 2008 / Accepted: 17 September 2008 / Published online: 12 February 2009 Springer-Verlag 2009 Abstract The synthesis of new substituted prolines carrying at C-4 a second a-amino acid residue is reported. The amino acid, L-cysteine or L-selenocysteine, is linked to the proline ring through the sulfur or the selenium atom, respectively. The products were prepared with different stereochemistry at C-4, in few and clean high-yielding

Transglutaminase-dependent antiproliferative and differentiative properties of nimesulide on B16-F10 mouse melanoma cells

ORIGINAL ARTICLE Angelo Gismondi Æ Alessandro Lentini Æ Claudio Tabolacci Æ Bruno Provenzano Æ Simone Beninati Received: 9 October 2008 / Accepted: 10 December 2008 / Published online: 12 February 2009 Springer-Verlag 2009 Abstract The aim of this study was to collect evidences on the role of transglutaminase (TG, E.C. in the antineoplastic properties exerted by nimesulide (NMS), a non-steroidal anti-inflammatory drug, on murine B16-F10 melanoma cells. Treatment of melanoma cells with

Application of protein grey incidence degree measure to predict protein quaternary structural types

ORIGINAL ARTICLE Xuan Xiao Æ Wei-Zhong Lin Received: 23 August 2008 / Accepted: 10 November 2008 / Published online: 27 November 2008 Springer-Verlag 2008 Abstract Many proteins are composed of two or more subunits, each associated with different polypeptide chains. The number and arrangement of subunits forming a protein are referred to as quaternary structure. It has been known for long that the functions of proteins are closely related to their quaternary structure. In this paper the grey incidence degree is introduced that can calculate the numerical
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