Нанотехнология

Study of hepatotoxicity of naltrexone in the treatment of alcoholism Mao-Hsiung Yena, Huei-Chen Kob, Fu-In Tangc, Ru-Band Lub,d,*, Jau-Shyong Honge

Русский
Аннотация научной статьи: 

Since a black box warning was issued by the Food and Drug Administration regarding the use of the opiate antagonist naltrexone (NTX),
many clinicians have been concerned about current labeling of the potential hepatotoxicity risk of NTX in the treatment of opiate dependence

Changes in the endorphin and serotonin content of rat immune cells during adulthood following maternal exposure to ethanol during pregnancy and lactation

Русский
Аннотация научной статьи: 

Lactating and lactating/pregnant rat dams consumed either 3% (vol/vol) ethanol (as the sole source of fluid) between the 1st and 21st
days after delivery or 15% (vol/vol) ethanol for 24 h on the 3rd day after delivery. Offspring of ethanol-consuming dams were compared

Reversal learning after prenatal or early postnatal alcohol exposure in juvenile and adult rats

Русский
Аннотация научной статьи: 

Learning tasks that require the reversal of a previously learned contingency are disrupted in animals and humans exposed to alcohol
during the perinatal period. The current experiments examined how varying the time of alcohol exposure and the age at which subjects

Comparison of chronic ethanol and chronic intermittent ethanol treatments on the expression of GABAA and NMDA receptor subunits

Русский
Аннотация научной статьи: 

We examined the mRNA and protein levels of GABAA and NMDA receptor (NMDAR) subunits in cultured mouse cortical neurons
following exposure to chronic ethanol (CE) or chronic intermittent ethanol (CIE), and after 5 days of withdrawal. With respect to GABAA

Alcohol seeking in C57BL/6 mice induced by conditioned cues and contexts in the extinction-reinstatement model

Русский
Аннотация научной статьи: 

We have recently shown that the alcohol self-administration context can reinstate extinguished responding for alcohol when that extinction
occurs in a different context [Burattini, C., Gill, T. M., Aicardi, G., & Janak, P. H. (2006)]. The ethanol self-administration context as

Increased expression of 5-HT1B receptors in rat nucleus accumbens via virally mediated gene transfer increases voluntary alcohol consumption

Русский
Аннотация научной статьи: 

Serotonin 5-HT1B receptors have been linked to alcoholism in humans and alcohol consumption in rodents. We hypothesize that these
receptors, which are located on the axon terminals of nucleus accumbens’ (NAcc) projection neurons, modulate alcohol reward mechanisms.

Chronic alcoholism alters the transport characteristics of folate in rat renal brush border membrane

Русский
Аннотация научной статьи: 

Folic acid transport across the epithelial cell membrane of kidney tubules is an essential step for its reabsorption, conservation, and homeostasis
in the body. We characterized [3H]-folic acid transport in renal brush border membrane vesicles after 12 weeks of chronic ethanol

Ethanol impairs CCK-8-evoked amylase secretion through Ca21- mediated ROS generation in mouse pancreatic acinar cells

Русский
Аннотация научной статьи: 

In the present study, we have investigated the effect of ethanol on amylase release in response to cholecystokinin octapeptide (CCK-8).We
have also studied the effect of ethanol on cytosolic free Ca21 concentration ([Ca21]c) and reactive oxygen species (ROS) production by loading

Serum cytokeratins in alcoholic liver disease: contrasting levels of cytokeratin-18 and cytokeratin-19

Русский
Аннотация научной статьи: 

Serum cytokeratin (CK) levels are widely used as tumor markers. Serum levels of CK-18, a tumor marker also known as tissue polypeptide
specific antigen (TPS), are increased in patients with alcoholic liver disease. Cytokeratin-18 is the main component of Mallory

Saturation of retinol-binding protein correlates closely to the severity of alcohol-induced liver disease

Русский
Аннотация научной статьи: 

Impaired metabolism of retinol has been shown to occur in alcohol-induced liver disease (ALD). The purpose of the present study was to
investigate the saturation of retinol-binding protein (RBP) in 6 patients with different stages of ALD. Hospitalized alcohol consumers

Страницы

Подписаться на Нанотехнология