Acute tryptophan depletion does not improve endurance cycling capacity in a warm environment

ORIGINAL ARTICLE Ruth M. Hobson • Phillip Watson • Ronald J. Maughan Received: 10 July 2012 / Accepted: 6 November 2012 / Published online: 21 November 2012 Springer-Verlag Wien 2012 Abstract Newsholme’s theory of central fatigue suggests that acute tryptophan depletion should improve endurance exercise capacity in a warm environment by reducing serotonergic activity in the brain. Eight males cycled to volitional exhaustion at 55 % V _O2 peak in 30.1 ± 0.5 C and 30 ± 7 % relative humidity on two separate occasions, after consuming either an amino acid load to deplete their

Synthesis of gem-diamino acid derivatives by a Hofmann rearrangement

ORIGINAL ARTICLE Emanuele Aresu • Stefania Fioravanti • Simona Gasbarri • Lucio Pellacani • Federico Ramadori Received: 26 September 2012 / Accepted: 4 November 2012 / Published online: 22 November 2012 Springer-Verlag Wien 2012 Abstract Starting from commercially available N-protected L-a-amino acids, N,N0-protected gem-diaminic units were obtained by a two-step methodology. A Hofmann reaction performed using a primary alcohol as the solvent to trap the isocyanate intermediate represents the key step of the new synthetic procedure. Then, the methodology

Combination of BCAAs and glutamine enhances dermal collagen protein synthesis in protein-malnourished rats

ORIGINAL ARTICLE Hitoshi Murakami • Kazutaka Shimbo • Yoshinobu Takino • Hisamine Kobayashi Received: 6 September 2012 / Accepted: 25 October 2012 / Published online: 8 November 2012 Springer-Verlag Wien 2012 Abstract Skin collagen decreases in protein-malnourished states. Amino acids regulate protein metabolism, glutamine stimulates collagen synthesis through the conversion process to proline and provides 75 % of the intracellular free proline in fibroblasts. However, the impact of these amino acids on collagen synthesis under malnutrition has not been

Vaspin attenuates the apoptosis of human osteoblasts through ERK signaling pathway

ORIGINAL ARTICLE Xiao Zhu • Yi Jiang • Peng-Fei Shan • Jie Shen • Qiu-Hua Liang • Rong-Rong Cui • Yuan Liu • Guan-Ying Liu • Shan-Shan Wu • Qiong Lu • Hui Xie • You-Shuo Liu • Ling-Qing Yuan • Er-Yuan Liao Received: 6 July 2012 / Accepted: 22 October 2012 / Published online: 8 November 2012 Springer-Verlag Wien 2012 Abstract It has been hypothesized that adipocytokines originating from adipose tissue may have an important role in bone metabolism. Vaspin is a novel adipocytokine isolated from visceral white adipose tissue, which has been

PEGylated dendrimer polystyrene support: synthesis, characterisation and evaluation of biologically active peptides

ORIGINAL ARTICLE M. A. Siyad • G. S. Vinod Kumar Received: 17 June 2012 / Accepted: 12 October 2012 / Published online: 1 November 2012 Springer-Verlag Wien 2012 Abstract Poly(N,N-bisethylamine) dendrimers with high content of poly(ethylene glycol) were synthesized on 3-(Acryloyloxy)-2-hydroxypropylmethacrylate-crosslinked polystyrene (PS-AHMA) resin and tested in various conditions of solid phase peptide synthesis. The dendritic templates were generated to the second generation on

Synthesis, characterization, conformational analysis of a cyclic conjugated octreotate peptide and biological evaluation of 99mTc-HYNIC-His3-Octreotate as novel tracer for the imaging of somatostatin receptor-positive tumors

ORIGINAL ARTICLE Ashok Behera • Indranil Banerjee • Kakali De • Rudra Narayan Munda • Sankha Chattopadhayay • Amalesh Samanta • Bharat Sarkar • Santanu Ganguly • Mridula Misra Received: 28 June 2012 / Accepted: 12 October 2012 / Published online: 23 October 2012 Springer-Verlag Wien 2012 Abstract Peptides are attracting increasing interest in nuclear oncology for targeted tumor diagnosis and therapy. We therefore synthesized new cyclic octapeptides conjugated with HYNIC by Fmoc solid-phase peptide synthesis. These were purified and analyzed by RP-HPLC, MALDI

Glycine reduces platelet aggregation

ORIGINAL ARTICLE Peter Schemmer • Zhi Zhong • Uwe Galli • Michael D. Wheeler • Li Xiangli • Blair U. Bradford • Lars O. Conzelmann • Dow Forman • Jose ´ Boyer • Ronald G. Thurman Received: 7 August 2012 / Accepted: 11 October 2012 / Published online: 8 November 2012 Springer-Verlag Wien 2012 Abstract It has been demonstrated that a wide variety of white blood cells and macrophages (i.e. Kupffer cells, alveolar and peritoneal macrophages and neutrophils) contain glycine-gated chloride channels. Binding of glycine on the receptor stimulates Cl- influx causing membrane

Dietary supplementation with monosodium glutamate is safe and improves growth performance in postweaning pigs

ORIGINAL ARTICLE Reza Rezaei • Darrell A. Knabe • Carmen D. Tekwe • Sudath Dahanayaka • Martin D. Ficken • Susan E. Fielder • Sarah J. Eide • Sandra L. Lovering • Guoyao Wu Received: 5 October 2012 / Accepted: 9 October 2012 / Published online: 2 November 2012 Springer-Verlag Wien 2012 Abstract Dietary intake of glutamate by postweaning pigs is markedly reduced due to low feed consumption. This study was conducted to determine the safety and efficacy of dietary supplementation with monosodium glutamate (MSG) in postweaning pigs. Piglets were weaned at 21 days of age to a

The influence of exogenous carbohydrate provision and pre-exercise alkalosis on the heat shock protein response to prolonged interval cycling

ORIGINAL ARTICLE Daniel J. Peart • Richard J. Kirk • Leigh A. Madden • Jason C. Siegler • Rebecca V. Vince Received: 18 April 2012 / Accepted: 8 October 2012 / Published online: 23 October 2012 Springer-Verlag Wien 2012 Abstract The aim of this study was to observe the intracellular heat shock protein 72 (HSP72) and heme oxygenase-1 (HSP32) response to prolonged interval cycling following the ingestion of carbohydrates (CHO) and sodium bicarbonate (NaHCO3). Six recreationally active males (mean ± SD; age 23.2 ± 2.9 years, height 179.5 ± 5.5 cm, body mass 76.5 ± 6.8 kg, and peak power output

An empirical study on the matrix-based protein representations and their combination with sequence-based approaches

ORIGINAL ARTICLE Loris Nanni • Alessandra Lumini • Sheryl Brahnam Received: 15 March 2012 / Accepted: 3 October 2012 / Published online: 30 October 2012 Springer-Verlag Wien 2012 Abstract Many domains have a stake in the development of reliable systems for automatic protein classification. Of particular interest in recent studies of automatic protein classification is the exploration of new methods for extracting features from a protein that enhance classification for specific problems. These methods have proven very


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