Биохимия

The influence of exogenous carbohydrate provision and pre-exercise alkalosis on the heat shock protein response to prolonged interval cycling

ORIGINAL ARTICLE Daniel J. Peart • Richard J. Kirk • Leigh A. Madden • Jason C. Siegler • Rebecca V. Vince Received: 18 April 2012 / Accepted: 8 October 2012 / Published online: 23 October 2012 Springer-Verlag Wien 2012 Abstract The aim of this study was to observe the intracellular heat shock protein 72 (HSP72) and heme oxygenase-1 (HSP32) response to prolonged interval cycling following the ingestion of carbohydrates (CHO) and sodium bicarbonate (NaHCO3). Six recreationally active males (mean ± SD; age 23.2 ± 2.9 years, height 179.5 ± 5.5 cm, body mass 76.5 ± 6.8 kg, and peak power output

An empirical study on the matrix-based protein representations and their combination with sequence-based approaches

ORIGINAL ARTICLE Loris Nanni • Alessandra Lumini • Sheryl Brahnam Received: 15 March 2012 / Accepted: 3 October 2012 / Published online: 30 October 2012 Springer-Verlag Wien 2012 Abstract Many domains have a stake in the development of reliable systems for automatic protein classification. Of particular interest in recent studies of automatic protein classification is the exploration of new methods for extracting features from a protein that enhance classification for specific problems. These methods have proven very

Urocortin 1 administered into the hypothalamic supraoptic nucleus inhibits food intake in freely fed and food-deprived rats

ORIGINAL ARTICLE A. Fatima • S. Andrabi • G. Wolf • M. Engelmann • M. G. Spina Received: 1 February 2012 / Accepted: 1 October 2012 / Published online: 18 October 2012 Springer-Verlag Wien 2012 Abstract Peptides of the corticotropin-releasing hormone/Urocortin (CRH/Ucn) family are known to suppress appetite primarily via CRH2 receptors. In the rat hypothalamic supraoptic nucleus (SON), synthesis of both Ucn1 and CRH2 receptors has been reported, yet little is known about the effects of Ucn1 in the SON on feeding behaviour. We first established the dose-related effects of Ucn1

Modulation of ethanol effect on hepatocyte proliferation by polyamines

ORIGINAL ARTICLE T. H. T. Do • F. Gaboriau • I. Morel • S. Lepage • I. Cannie • O. Lore ´al • G. Lescoat Received: 8 April 2012 / Accepted: 28 September 2012 / Published online: 11 October 2012 Springer-Verlag Wien 2012 Abstract An occurrence and a magnitude of alcoholic liver diseases depend on the balance between ethanolinduced injury and liver regeneration. Like ethanol, polyamines including putrescine, spermidine, and spermine modulate cell proliferation. Thus, the purpose of this study was to evaluate the relationship between effect of ethanol

Acute creatine administration improves mitochondrial membrane potential and protects against pentylenetetrazol-induced seizures

ORIGINAL ARTICLE Leonardo Magno Rambo • Leandro Rodrigo Ribeiro • Iuri Domingues Della-Pace • Daniel Neis Stamm • Roge ´rio da Rosa Gerbatin • Marina Prigol • Simone Pinton • Cristina Wayne Nogueira • Ana Fla ´via Furian • Mauro Schneider Oliveira • Michele Rechia Fighera • Luiz Fernando Freire Royes Received: 3 March 2012 / Accepted: 24 September 2012 / Published online: 12 October 2012 Springer-Verlag Wien 2012 Abstract A growing body of evidence indicates that creatine (Cr) exerts beneficial effects on a variety of pathologies where energy metabolism and oxidative stress

Structure-based prediction of the effects of a missense variant on protein stability

ORIGINAL ARTICLE Yang Yang • Biao Chen • Ge Tan • Mauno Vihinen • Bairong Shen Received: 12 June 2012 / Accepted: 23 September 2012 / Published online: 12 October 2012 Springer-Verlag Wien 2012 Abstract Predicting the effects of amino acid substitutions on protein stability provides invaluable information for protein design, the assignment of biological function, and for understanding disease-associated variations. To understand the effects of substitutions, computational models are preferred to time-consuming and expensive

Short peptide constructs mimic agonist sites of AT1R and BK receptors

ORIGINAL ARTICLE Douglas D. Lopes • Renata F. F. Vieira • Luciana Malavolta • Erick F. Poletti • Suma I. Shimuta • Antonio C. M. Paiva • Shirley Schreier • Laerte Oliveira • Clovis R. Nakaie Received: 2 July 2012 / Accepted: 17 September 2012 / Published online: 25 October 2012 Springer-Verlag Wien 2012 Abstract Extracellular peptide ligand binding sites, which bind the N-termini of angiotensin II (AngII) and bradykinin (BK) peptides, are located on the N-terminal and extracellular loop 3 regions of the AT1R and BKRB1 or BKRB2 G-protein-coupled receptors (GPCRs). Here we

Cationic membrane peptides: atomic-level insight of structure–activity relationships from solid-state NMR

INVITED REVIEW Yongchao Su • Shenhui Li • Mei Hong Received: 9 October 2012 / Accepted: 11 October 2012 / Published online: 30 October 2012 Springer-Verlag Wien 2012 Abstract Many membrane-active peptides, such as cationic cell-penetrating peptides (CPPs) and antimicrobial peptides (AMPs), conduct their biological functions by interacting with the cell membrane. The interactions of charged residues with lipids and water facilitate membrane insertion, translocation or disruption of these highly hydrophobic species. In this review, we will summarize

Antioxidative peptides: enzymatic production, in vitro and in vivo antioxidant activity and potential applications of milk-derived antioxidative peptides

REVIEW ARTICLE O. Power • P. Jakeman • R. J. FitzGerald Received: 30 May 2012 / Accepted: 21 August 2012 / Published online: 12 September 2012 Springer-Verlag 2012 Abstract The beneficial effects of food-derived antioxidants in health promotion and disease prevention are being increasingly recognized. Recently, there has been a particular focus on milk-derived peptides; as a source of antioxidants, these peptides are inactive within the sequence of the parent protein but can be released during enzyme hydrolysis. Once released, the peptides have been

Synthesis of polysubstituted b-amino cyclohexane carboxylic acids via Diels–Alder reaction using Ni(II)-complex stabilized b-alanine derived dienes

ORIGINAL ARTICLE Xiao Ding • Hengshuai Wang • Jiang Wang • Sinan Wang • Daizong Lin • Li Lv • Yu Zhou • Xiaomin Luo • Hualiang Jiang • Jose ´ Luis Acen ˜a • Vadim A. Soloshonok • Hong Liu Received: 17 April 2012 / Accepted: 14 September 2012 / Published online: 30 September 2012 Springer-Verlag Wien 2012 Abstract This paper describes the design and synthesis of a new class of b-alanine derived dienes stabilized by Ni(II)-complex. Preliminary study of their Diels–Alder cycloaddition reactions with several types of dienophiles demonstrates their significant synthetic potential for the

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