Биохимия

Astroglial amino acid-based transmitter receptors

INVITED REVIEW Vladimir Parpura • Alexei Verkhratsky Received: 31 December 2012 / Accepted: 2 January 2013 / Published online: 26 January 2013 Springer-Verlag Wien 2013 Abstract Amino acids appear in prebiotic period being one of the first organic molecules on Earth. For neurobiologists, it is of importance that AAs are not only representing building blocks of life, but are also the essential part of metabolism and cellular signaling. In the mammalian brain, the most common excitatory and inhibitory transmitters acting upon cellular plasmalemmal receptors

Potency of GABA at human recombinant GABAA receptors expressed in Xenopus oocytes: a mini review

INVITED REVIEW Nasiara Karim • Petrine Wellendorph • Nathan Absalom • Graham A. R. Johnston • Jane R. Hanrahan • Mary Chebib Received: 23 December 2012 / Accepted: 26 December 2012 / Published online: 6 February 2013 Springer-Verlag Wien 2013 Abstract GABAA receptors are members of the ligandgated ion channel superfamily that mediate inhibitory neurotransmission in the central nervous system. They are thought to be composed of 2 alpha (a), 2 beta (b) subunits and one other such as a gamma (c) or delta (d) subunit. The

Crowdsourcing in proteomics: public resources lead to better experiments

INVITED REVIEW Harald Barsnes • Lennart Martens Received: 22 December 2012 / Accepted: 26 December 2012 / Published online: 2 February 2013 Springer-Verlag Wien 2013 Abstract With the growing interest in the field of proteomics, the amount of publicly available proteome resources has also increased dramatically. This means that there are many useful resources available for almost all aspects of a proteomics experiment. However, it remains vital to use the right resource, for the right purpose, at the right time. This review is therefore meant to aid the reader

Tenascins and inflammation in disorders of the nervous system

INVITED REVIEW Igor Jakovcevski • Djordje Miljkovic • Melitta Schachner • Pavle R. Andjus Received: 10 September 2012 / Accepted: 10 December 2012 / Published online: 27 December 2012 Springer-Verlag Wien 2012 Abstract In vitro and in vivo studies on the role of tenascins have shown that the two paradigmatic glycoproteins of the tenascin family, tenascin-C (TnC) and tenascin-R (TnR) play important roles in cell proliferation and migration, fate determination, axonal pathfinding, myelination, and synaptic plasticity. As components of the

Dietary requirements of ‘‘nutritionally non-essential amino acids’’ by animals and humans

INVITED REVIEW Guoyao Wu • Zhenlong Wu • Zhaolai Dai • Ying Yang • Weiwei Wang • Chuang Liu • Bin Wang • Junjun Wang • Yulong Yin Received: 25 November 2012 / Accepted: 2 December 2012 / Published online: 18 December 2012 Springer-Verlag Wien 2012 Abstract Amino acids are necessary for the survival, growth, development, reproduction and health of all organisms. They were traditionally classified as nutritionally essential or non-essential for mammals, birds and fish based on nitrogen balance or growth. It was assumed that all ‘‘non-essential amino acids (NEAA)’’ were synthesized

Oostatic peptides

REVIEW ARTICLE Jan Hlava ´c ˇek Received: 13 December 2012 / Accepted: 15 December 2012 / Published online: 8 January 2013 Springer-Verlag Wien 2013 Abstract Oostatic peptides are organic molecules, which influence an insect reproduction due to a regulation of the eggs development. It was proved that decapeptide—H-TyrAsp-Pro-Ala-Pro-Pro-Pro-Pro-Pro-Pro-OH (YDPAPPPPPP) —isolated from mosquito Aedes aegypti, inhibits trypsin activity in the midgut of the mosquito. Therefore, it was named trypsin-modulating oostatic factor (Aea-TMOF). Feeding the recombinant cells with cloned and expressed

An amino acid mixture improves glucose tolerance and lowers insulin resistance in the obese Zucker rat

ORIGINAL ARTICLE Jeffrey R. Bernard • Yi-Hung Liao • Zhenping Ding • Daisuke Hara • Maximilian Kleinert • Jeffrey L. Nelson • John L. Ivy Received: 2 December 2012 / Accepted: 11 March 2013 / Published online: 23 March 2013 Springer-Verlag Wien 2013 Abstract The purpose of this investigation was to test an amino acid mixture on glucose tolerance in obese Zucker rats [experiment (Exp)-1] and determine whether differences in blood glucose were associated with alterations in muscle glucose uptake [experiment (Exp)-2]. Exp-1 rats

Efficacy of L-proline administration on the early responses during cutaneous wound healing in rats

ORIGINAL ARTICLE Thangavel Ponrasu • Sankar Jamuna • Arulanandham Mathew • Karuppanan Natarajan Madhukumar • Moorthy Ganeshkumar • Kuttalam Iyappan • Lonchin Suguna Received: 3 August 2012 / Accepted: 5 March 2013 / Published online: 19 March 2013 Springer-Verlag Wien 2013 Abstract Proline (Pro) plays a versatile role in cell metabolism and physiology. Pro and hydroxypro are major imino acids present in collagen, an important connective tissue protein, essential for wound healing, which is a primary response to tissue injury. This study explains the

Side-effects of analgesic kyotorphin derivatives: advantages over clinical opioid drugs

ORIGINAL ARTICLE Marta M. B. Ribeiro • So ´nia Sa ´ Santos • David S. C. Sousa • Margarida Oliveira • Sara M. Santos • Montserrat Heras • Eduard Bardaji • Isaura Tavares • Miguel A. R. B. Castanho Received: 28 November 2012 / Accepted: 23 February 2013 / Published online: 8 March 2013 Springer-Verlag Wien 2013 Abstract The adverse side-effects associated with opioid administration restrain their use as analgesic drugs and call for new solutions to treat pain. Two kyotorphin derivatives, kyotorphin-amide (KTP–NH2) and ibuprofen–KTP–NH2 (IbKTP–NH2) are promising alternatives to opioids: they

Photophysics of novel coumarin-labeled depsipeptides in solution: sensing interactions with SDS micelle via TICT model

ORIGINAL ARTICLE Suvendu Biswas • Ilker Avan • Akash K. Basak • Nader E. Abo-Dya • Abdullah Asiri • Alan R. Katritzky Received: 8 August 2012 / Accepted: 23 February 2013 / Published online: 4 April 2013 Springer-Verlag Wien 2013 Abstract N-Acylbenzotriazoles enable the synthesis (69–92 % yield) of blue to green fluorescent coumarinlabeled depsidipeptides 8a–f (quantum yields 0.004–0.97) and depsitripeptides 12a–d (quantum yields 0.02–0.96). Detailed photophysical studies of fluorescent coumarinlabeled depsipeptides 8a–f and 12a–d are reported for both

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